Formulite^™- A Next Generation Bioavailability Enhancement Technology

Disruptive Pharma is an innovative clinical-stage pharmaceutical development company dedicated to transforming drugs with poor bioavailability into effective, patient-friendly oral solid dosage forms.

Formulite^™ High-Level Value Drivers
• Optimized bioavailability: Through improved solubility and absorption
• High drug loading in final product: Smaller tablets or capsules
• Cost-efficient manufacturing: Ideal for tableting and encapsulation
• Eco-friendly and biodegradable matrix: Reduced solvent and polymer use

 

FORMULITE

Business model and Partnering

Within the Product Candidates business area, we will seek commercial partnership or global licensing to industry partner(s) at or before clinical proof-of-concept has been demonstrated.
• Licensing agreement
• Milestone based development agreement
• Strategic co-development

Within the Technology Solutions business area, we offer different ways of working together;
• Licensing agreements – developing enabling formulations of partner assets
• Fee for service contracts – Technology provider and feasibility trials
• Co-development of partner assets – Mutually agreed development programs

Improving drug products with FORMULITE

By leveraging our proprietary Formulite^™ technology we can reformulate APIs to realize improved versions of selected products already on the market. The oral bioavailability of the API may be significantly enhanced by Formulite^™ resulting in a substantial API dose reduction with bioequivalent efficacy. This is expected to translate into lower inter-patient variability which also may improve API tolerability. Drugs based on APIs with poor water solubility typically exhibit high efficacy levels, but patients suffer from an unfavorable side effect profile, such as a high rate of gastro-intestinal complications.

Enabling new chemical entities with FORMULITE

Formulation of novel drug compounds may be challenging. The Formulite^™ technology offers several solutions for small molecule drug delivery needs. It does not matter if your drug compound exhibits poor water solubility or is difficult to formulate for other reasons. We can tailor make the best solution for your drug compound whether it is a new chemical entity (NCE) or an already known drug (API). A drug compound loaded into Formulite^™ can be directly filled into capsules. This means that one uniform Formulite^™ formulation can be used in all pre-clinical studies, through the clinical program, and finally the commercial product. Through Formulite^™ your formulation challenges are mitigated, the technical development risk is reduced and development time due to reformulation is kept at a minimum.